prof. dr hab. Andrzej Bojarski

prof. dr hab. Andrzej Bojarski

+48 12 6623365
pokój 325
Zakład Chemii Leków

Dokonania naukowe

  • Publikacje

A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties

Autorzy: Canale, Vittorio, Grychowska, Katarzyna, Kurczab, Rafal, Ryng, Mateusz, Keeri, Abdul Raheem, Satala, Grzegorz, Olejarz-Maciej, Agnieszka, Koczurkiewicz, Paulina, Drop, Marcin, Blicharz, Klaudia, Piska, Kamil, Pekala, Elzbieta, Janiszewska, Paulina, Krawczyk, Martyna, Walczak, Maria, Chaumont-Dubel, Severine, Bojarski, Andrzej J., Marin, Philippe, Popik, Piotr, Zajdel, Pawel

DOI: 10.1016/J.EJMECH.2020.112765
Date: 2020-01-01

Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors

Autorzy: Nizi, Maria Giulia, Desantis, Jenny, Nakatani, Yoshio, Massari, Serena, Mazzarella, Maria Angela, Shetye, Gauri, Sabatini, Stefano, Barreca, Maria Letizia, Manfroni, Giuseppe, Felicetti, Tommaso, Rushton-Green, Rowena, Hards, Kiel, Latacz, Gniewomir, Satala, Grzegorz, Bojarski, Andrzej J., Cecchetti, Violetta, Kolar, Michal H., Handzlik, Jadwiga, Cook, Gregory M., Franzblau, Scott G., Tabarrini, Oriana

DOI: 10.1016/J.EJMECH.2020.112420
Date: 2020-01-01

mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Autorzy: Martin, Pierre-Yves, Doly, Stephane, Hamieh, Al Mahdy, Chapuy, Eric, Canale, Vittorio, Drop, Marcin, Chaumont-Dubel, Severine, Bantreil, Xavier, Lamaty, Frederic, Bojarski, Andrzej J., Zajdel, Pawel, Eschalier, Alain, Marin, Philippe, Courteix, Christine

DOI: 10.1016/J.PNEUROBIO.2020.101846
Date: 2020-01-01

Virtual screening-driven discovery of dual 5-HT<sub>6</sub>/5-HT<sub>2A</sub> receptor ligands with pro-cognitive properties

Autorzy: Staron, Jakub, Kurczab, Rafal, Warszycki, Dawid, Satala, Grzegorz, Krawczyk, Martyna, Bugno, Ryszard, Lenda, Tomasz, Popik, Piotr, Hogendorf, Adam S., Hogendorf, Agata, Dubiel, Krzysztof, Matloka, Mikolaj, Moszczynski-Petkowski, Rafat, Pieczykolan, Jerzy, Wieczorek, Maciej, Zajdel, Pawel, Bojarski, Andrzej J.

DOI: 10.1016/J.EJMECH.2019.111857
Date: 2020-01-01

Identification of a Potent and Selective 5-HT<sub>1A</sub> Receptor Agonist with <i>In Vitro</i> and <i>In Vivo</i> Antinociceptive Activity

Autorzy: Linciano, Pasquale, Sorbi, Claudia, Comitato, Antonella, Lesniak, Anna, Bujalska-Zadrozny, Magdalena, Pawlowska, Agata, Bielenica, Anna, Orzelska-Gorka, Jolanta, Kedzierska, Ewa, Biala, Grazyna, Ronsisvalle, Simone, Limoncella, Silvia, Casarini, Livio, Cichero, Elena, Fossa, Paola, Satala, Grzegorz, Bojarski, Andrzej J., Brasili, Livio, Bardoni, Rita, Franchini, Silvia

DOI: 10.1021/ACSCHEMNEURO.0C00289
Date: 2020-01-01

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT<sub>1A</sub>/5-HT<sub>7</sub> receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity

Autorzy: Jankowska, Agnieszka, Satala, Grzegorz, Kolaczkowski, Marcin, Bucki, Adam, Gluch-Lutwin, Monika, Swierczek, Artur, Pociecha, Krzysztof, Partyka, Anna, Jastrzebska-Wiesek, Magdalena, Lubelska, Annamaria, Latacz, Gniewomir, Gawalska, Alicja, Bojarski, Andrzej J., Wyska, Elzbieta, Chlon-Rzepa, Grazyna

DOI: 10.1016/J.EJMECH.2020.112437
Date: 2020-01-01

In Silico Methods for the Discovery of Orthosteric GABA<sub>B</sub> Receptor Compounds

Autorzy: Linn M. Evenseth, Dawid Warszycki, Andrzej Bojarski, Mari Gabrielsen, Ingebrigt Sylte

DOI: 10.3390/molecules24050935
Date: 2019-03-01

Development of New Methods Needs Proper Evaluation-Benchmarking Sets for Machine Learning Experiments for Class A GPCRs

Autorzy: Lesniak, Damian, Podlewska, Sabina, Jastrzebski, Stanislaw, Sieradzki, Igor, Bojarski, Andrzej J., Tabor, Jacek

DOI: 10.1021/ACS.JCIM.9B00689
Date: 2019-01-01

Aminergic GPCR-Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

Autorzy: Vass, Marton, Podlewska, Sabina, de Esch, Iwan J. P., Bojarski, Andrzej J., Leurs, Rob, Kooistra, Albert J., de Graaf, Chris

DOI: 10.1021/ACS.JMEDCHEM.8B00836
Date: 2019-01-01

2-Aminoimidazole-based antagonists of the 5-HT<sub>6</sub> receptor - A new concept in aminergic GPCR ligand design

Autorzy: Hogendorf, Adam S., Hogendorf, Agata, Kurczab, Rafal, Kalinowska-Tluscik, Justyna, Popik, Piotr, Nikiforuk, Agnieszka, Krawczyk, Martyna, Satala, Grzegorz, Lenda, Tomasz, Knutelska, Joanna, Bugno, Ryszard, Staron, Jakub, Pietrus, Wojciech, Matloka, Mikolaj, Dubiel, Krzysztof, Moszczynski-Petkowski, Rafal, Pieczykolan, Jerzy, Wieczorek, Maciej, Pilarski, Boguslaw, Zajdel, Pawel, Bojarski, Andrzej J.

DOI: 10.1016/J.EJMECH.2019.06.001
Date: 2019-01-01

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