prof. dr hab. Andrzej Bojarski

prof. dr hab. Andrzej Bojarski

+48 12 6623365
pokój 325
Zakład Chemii Leków

Dokonania naukowe

  • Publikacje

Neuropathic pain-alleviating activity of novel 5-HT<sub>6</sub> receptor inverse agonists derived from 2-aryl-1<i>H</i>-pyrrole-3-carboxamide

Autorzy: Drop, Marcin, Jacquot, Florian, Canale, Vittorio, Chaumont-Dubel, Severine, Walczak, Maria, Satala, Grzegorz, Nosalska, Klaudia, Mahoro, Gilbert Umuhire, Sloczynska, Karolina, Piska, Kamil, Lamoine, Sylvain, Pekala, Elzbieta, Masurier, Nicolas, Bojarski, Andrzej J., Pawlowski, Maciej, Martinez, Jean, Subra, Gilles, Bantreil, Xavier, Lamaty, Frederic, Eschalier, Alain, Marin, Philippe, Courteix, Christine, Zajdel, Pawel

DOI: 10.1016/J.BIOORG.2021.105218
Date: 2021-01-01

2-Phenyl-1<i>H</i>-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT<sub>6</sub> Receptor Inverse Agonists with Cognition-Enhancing Activity

Autorzy: Drop, Marcin, Canale, Vittorio, Chaumont-Dubel, Severine, Kurczab, Rafal, Satala, Grzegorz, Bantreil, Xavier, Walczak, Maria, Koczurkiewicz-Adamczyk, Paulina, Latacz, Gniewomir, Gwizdak, Anna, Krawczyk, Martyna, Golebiowska, Joanna, Grychowska, Katarzyna, Bojarski, Andrzej J., Nikiforuk, Agnieszka, Subra, Gilles, Martinez, Jean, Pawlowski, Maciej, Popik, Piotr, Marin, Philippe, Lamaty, Frederic, Zajdel, Pawel

DOI: 10.1021/ACSCHEMNEURO.1C00061
Date: 2021-01-01

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT<sub>3</sub> and 5-HT<sub>6</sub> Receptor Antagonist with Antipsychotic and Procognitive Properties

Autorzy: Zajdel, Pawel, Grychowska, Katarzyna, Mogilski, Szczepan, Kurczab, Rafal, Satala, Grzegorz, Bugno, Ryszard, Kos, Tomasz, Golebiowska, Joanna, Malikowska-Racia, Natalia, Nikiforuk, Agnieszka, Chaumont-Dubel, Severine, Bantreil, Xavier, Pawlowski, Maciej, Martinez, Jean, Subra, Gilles, Lamaty, Frederic, Marin, Philippe, Bojarski, Andrzej J., Popik, Piotr

DOI: 10.1021/ACS.JMEDCHEM.1C00224
Date: 2021-01-01

Enzymatic Δ<SUP>1</SUP>-Dehydrogenation of 3-Ketosteroids-Reconciliation of Kinetic Isotope Effects with the Reaction Mechanism

Autorzy: Glanowski, Michal, Wojcik, Patrycja, Procner, Magdalena, Borowski, Tomasz, Lupa, Dawid, Mielczarek, Przemyslaw, Oszajca, Maria, Swiderek, Katarzyna, Moliner, Vicent, Bojarski, Andrzej J., Szaleniec, Maciej

DOI: 10.1021/ACSCATAL.1C01479
Date: 2021-01-01

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2

Autorzy: Sabina Podlewska, Ryszard Bugno, Enza Lacivita, Marcello Leopoldo, Andrzej Bojarski, Jadwiga Handzlik

DOI: 10.3390/ijms22031035
Date: 2021-01-01

A new class of 5-HT<sub>1A</sub> receptor antagonists with procognitive and antidepressant properties

Autorzy: Jankowska, Agnieszka, Satala, Grzegorz, Swierczek, Artur, Pociecha, Krzysztof, Partyka, Anna, Jastrzebska-Wiesek, Magdalena, Gluch-Lutwin, Monika, Bojarski, Andrzej J., Wyska, Elzbieta, Chlon-Rzepa, Grazyna

DOI: 10.4155/FMC-2020-0363
Date: 2021-01-01

Influence of a G protein-biased μ-opioid receptor agonist, PZM21, on behavioural response to stress and anxiogenic conditions

Autorzy: Kudla, L., Bugno, R., Bojarski, A., Przewlocki, R.

DOI: 10.1016/J.EURONEURO.2021.10.764
Date: 2021-01-01

Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data

Autorzy: Sabina Podlewska, Ryszard Bugno, Lucja Kudla, Andrzej Bojarski, Ryszard Przewlocki

DOI: 10.3390/molecules25204636
Date: 2020-10-01

Emulating Docking Results Using a Deep Neural Network: A New Perspective for Virtual Screening

Autorzy: Jastrzebski, Stanislaw, Szymczak, Maciej, Pocha, Agnieszka, Mordalski, Stefan, Tabor, Jacek, Bojarski, Andrzej J., Podlewska, Sabina

DOI: 10.1021/ACS.JCIM.9B01202
Date: 2020-01-01

Synthesis, crystal structure and biological activity of novel analogues of tricyclic drugs

Autorzy: Bieszczad, Bartosz, Siwek, Agata, Wilczek, Marcin, Trzybinski, Damian, Wozniak, Krzysztof, Satala, Grzegorz, Bojarski, Andrzej J., Mieczkowski, Adam

DOI: 10.1016/J.BMCL.2020.127493
Date: 2020-01-01

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