prof. dr hab. Andrzej Bojarski

prof. dr hab. Andrzej Bojarski

+48 12 6623365
pokój 325
Zakład Chemii Leków

Dokonania naukowe

  • Publikacje

Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1<i>H</i>-indol-3-yl)pyrrolidine-2,5-dione Derivatives with Affinity for the Serotonin Transporter

Autorzy: Martyna Wróbel, Andrzej Chodkowski, Agata Siwek, Grzegorz Satała, Andrzej Bojarski, Maciej Dawidowski

DOI: 10.3390/ijms252011276
Date: 2024-10-01

Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu<sub>7</sub> Receptor Modulation Activity and Antipsychotic-Like Properties

Autorzy: Katarzyna Kaczorowska, Anna Stankiewicz, Ryszard Bugno, Maria H. Paluchowska, Piotr Brański, Paulina Cieślik, Joanna M. Wierońska, Mariusz Milik, Mateusz Nowak, Agnieszka Przybyłowicz, Aneta Kozioł, Agata Hogendorf, Adam Hogendorf, Justyna Kalinowska-Tłuścik, Beata Duszyńska, Andrzej Pilc, Andrzej Bojarski

DOI: 10.3390/ijms24031981
Date: 2023-01-01

Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT<sub>6</sub> and D<sub>3</sub>R Affinity in the 1<i>H</i>-pyrrolo[3,2-<i>c</i>]quinoline Series

Autorzy: Katarzyna Grychowska, Wojciech Pietruś, Ludmiła Kulawik, Ophélie Bento, Grzegorz Satała, Xavier Bantreil, Frédéric Lamaty, Andrzej Bojarski, Joanna Gołębiowska, Agnieszka Nikiforuk, Philippe Marin, Séverine Chaumont-Dubel, Rafał Kurczab, Paweł Zajdel

DOI: 10.3390/molecules28031096
Date: 2023-01-01

Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands

Autorzy: Wojciech Pietruś, Rafał Kurczab, Dawid Warszycki, Andrzej Bojarski, Jürgen Bajorath

DOI: 10.3390/molecules28020490
Date: 2023-01-01

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT<sub>6</sub>R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity

Autorzy: Vittorio Canale, Wojciech Trybała, Séverine Chaumont-Dubel, Paulina Koczurkiewicz-Adamczyk, Grzegorz Satała, Ophélie Bento, Klaudia Blicharz-Futera, Xavier Bantreil, Elżbieta Pękala, Andrzej Bojarski, Frédéric Lamaty, Philippe Marin, Paweł Zajdel

DOI: 10.3390/biom13010012
Date: 2022-12-01

Hydrogen Bonds with Fluorine in Ligand–Protein Complexes-the PDB Analysis and Energy Calculations

Autorzy: Wojciech Pietruś, Rafał Kafel, Andrzej Bojarski, Rafał Kurczab

DOI: 10.3390/molecules27031005
Date: 2022-02-01

An Attempt to Achieve Hydrated Imidazoline Ring Expansion (HIRE) of Diarene-Fused [1,4]Diazepinones Delivers Selective Dopamine D-2 Receptor Ligands

Autorzy: Grintsevich, Sergey, Sapegin, Alexander, Duszynska, Beata, Bojarski, Andrzej J., Krasavin, Mikhail

DOI: 10.1055/A-1649-5317
Date: 2022-01-01

In Vitro and In Silico Analysis of the Residence Time of Serotonin 5-HT7 Receptor Ligands with Arylpiperazine Structure: A Structure- Kinetics Relationship Study

Autorzy: Penna, Eduardo, Niso, Mauro, Podlewska, Sabina, Volpicelli, Floriana, Crispino, Marianna, Perrone-Capano, Carla, Bojarski, Andrzej J., Lacivita, Enza, Leopoldo, Marcello

DOI: 10.1021/ACSCHEMNEURO.1C00710
Date: 2022-01-01

Mining anion-aromatic interactions in the Protein Data Bank

Autorzy: Kuzniak-Glanowska, Emilia, Glanowski, Michal, Kurczab, Rafal, Bojarski, Andrzej J., Podgajny, Robert

DOI: 10.1039/D2SC00763K
Date: 2022-01-01

Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior

Autorzy: Bijata, Monika, Baczynska, Ewa, Mueller, Franziska E., Bijata, Krystian, Masternak, Julia, Krzystyniak, Adam, Szewczyk, Bernadeta, Siwiec, Marcin, Antoniuk, Svitlana, Roszkowska, Matylda, Figiel, Izabela, Magnowska, Marta, Olszynski, Krzysztof H., Wardak, Agnieszka D., Hogendorf, Adam, Ruszczycki, Blazej, Gorinski, Nataliya, Labus, Josephine, Stepien, Tomasz, Tarka, Sylwia, Bojarski, Andrzej J., Tokarski, Krzysztof, Filipkowski, Robert K., Ponimaskin, Evgeni, Wlodarczyk, Jakub

DOI: 10.1016/J.CELREP.2022.110532
Date: 2022-01-01

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