prof. dr hab. Andrzej Bojarski

prof. dr hab. Andrzej Bojarski

+48 12 6623365
pokój 325
Zakład Chemii Leków

Dokonania naukowe

  • Publikacje

A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors

Autorzy: Fidom, K., Isberg, V., Hauser, A.S., Mordalski, S., Lehto, T., Bojarski, A.J., Gloriam, D.E.

DOI: 10.1016/j.ymeth.2014.09.009
Date: 2015-01-01

Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT<inf>7</inf>)/5-Hydroxytryptamine 2A (5-HT<inf>2A</inf>) Receptor Antagonists and Evaluation by [<sup>18</sup>F]-PET Imaging in a Primate Brain

Autorzy: Deau, E., Robin, E., Voinea, R., Percina, N., Satała, G., Finaru, A.-L., Chartier, A., Tamagnan, G., Alagille, D., Bojarski, A.J., Morisset-Lopez, S., Suzenet, F., Guillaumet, G.

DOI: 10.1021/acs.jmedchem.5b00874
Date: 2015-01-01

Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent

Autorzy: Czopek, A., Kołaczkowski, M., Bucki, A., Byrtus, H., Pawłowski, M., Kazek, G., Bojarski, A.J., Piaskowska, A., Kalinowska-Tłücik, J., Partyka, A., Wesołowska, A.

DOI: 10.1016/j.bmc.2015.04.026
Date: 2015-01-01

New Arylpiperazinylalkyl Derivatives of 8-Alkoxy-purine-2,6-dione and Dihydro[1,3]oxazolo[2,3-f]purinedione Targeting the Serotonin 5-HT<inf>1A</inf>/5-HT<inf>2A</inf>/5-HT<inf>7</inf> and Dopamine D<inf>2</inf> Receptors

Autorzy: Chłoń-Rzepa, G., Zagórska, A., Bucki, A., Kołaczkowski, M., Pawłowski, M., Satała, G., Bojarski, A.J., Partyka, A., Wesołowska, A., Pȩkala, E., Słoczyńska, K.

DOI: 10.1002/ardp.201500015
Date: 2015-01-01

Synthesis of Some Aminophosphonates Bearing N-(Fluorophenyl)-piperazynyl Moiety and Their Activity toward Serotonin Receptors

Autorzy: Lewkowski, J., Jóźwiak, A., Tokarz, P., Zagórski, P.M., Hamera, R., Cal, D., Satała, G., Bojarski, A.J.

DOI: 10.1002/hc.21259
Date: 2015-01-01

Bioisosteric matrices for ligands of serotonin receptors

Autorzy: Warszycki, D., Mordalski, S., Staroń, J., Bojarski, A.J.

DOI: 10.1002/cmdc.201402563
Date: 2015-01-01

Robust optimization of SVM hyperparameters in the classification of bioactive compounds

Autorzy: Czarnecki, W.M., Podlewska, S., Bojarski, A.J.

DOI: 10.1186/s13321-015-0088-0
Date: 2015-01-01

Multiple conformational states in retrospective virtual screening - Homology models vs. crystal structures: Beta-2 adrenergic receptor case study

Autorzy: Mordalski, S., Witek, J., Smusz, S., Rataj, K., Bojarski, A.J.

DOI: 10.1186/s13321-015-0062-x
Date: 2015-01-01

Rational design of 5-HT<inf>6</inf>R ligands using a bioisosteric strategy: Synthesis, biological evaluation and molecular modelling

Autorzy: Staroń, J., Warszycki, D., Kalinowska-Tłus̈cik, J., Satała, G., Bojarski, A.J.

DOI: 10.1039/c5ra00054h
Date: 2015-01-01

Multi-step protocol for automatic evaluation of docking results based on machine learning methods - A case study of serotonin receptors 5-HT<inf>6</inf> and 5-HT<inf>7</inf>

Autorzy: Smusz, S., Mordalski, S., Witek, J., Rataj, K., Kafel, R., Bojarski, A.J.

DOI: 10.1021/ci500564b
Date: 2015-01-01

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