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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord.
Mika J, Rojewska E, Makuch W, Korostynski M, Luvisetto S, Marinelli S, Pavone F, Przewlocka B
DOI: 10.1016/j.neuroscience.2010.11.040
Identification of cis-regulatory elements in the mammalian genome: the cREMaG database.
Piechota M, Korostynski M, Przewlocki R
DOI: 10.1371/journal.pone.0012465
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum.
Piechota M, Korostynski M, Solecki W, Gieryk A, Slezak M, Bilecki W, Ziolkowska B, Kostrzewa E, Cymerman I, Swiech L, Jaworski J, Przewlocki R
DOI: 10.1186/gb-2010-11-5-r48
A polymorphism in exon 2 of the delta-opioid receptor affects nociception in response to specific agonists and antagonists in mice selectively bred for high and low analgesia.
Sacharczuk M, Lesniak A, Korostynski M, Przewlocki R, Lipkowski A, Jaszczak K, Sadowski B
DOI: 10.1016/j.pain.2010.03.017
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum
Piechota, M., Korostynski, M., Solecki, W., Gieryk, A., Slezak, M., Bilecki, W., Ziolkowska, B., Kostrzewa, E., Cymerman, I., Swiech, L., Jaworski, J., Przewlocki, R.
DOI: 10.1186/gb-2010-11-5-r48
Gene expression profiles in human ruptured and unruptured intracranial aneurysms: What is the role of inflammation?
Pera, J., Korostynski, M., Krzyszkowski, T., Czopek, J., Slowik, A., Dziedzic, T., Piechota, M., Stachura, K., Moskala, M., Przewlocki, R., Szczudlik, A.
DOI: 10.1161/STROKEAHA.109.562009
Identification of cis-regulatory elements in the mammalian genome: The cREMaG database
Piechota, M., Korostynski, M., Przewlocki, R.
DOI: 10.1371/journal.pone.0012465
Loss of the serum response factor in the dopamine system leads to hyperactivity
Parkitna, J.R., Bilbao, A., Rieker, C., Engblom, D., Piechota, M., Nordheim, A., Spanagel, R., Schü, G.
DOI: 10.1096/fj.09-151423
Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?
Pera J, Korostynski M, Krzyszkowski T, Czopek J, Slowik A, Dziedzic T, Piechota M, Stachura K, Moskala M, Przewlocki R, Szczudlik A
DOI: 10.1161/strokeaha.109.562009
Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain.
Mika J, Osikowicz M, Rojewska E, Korostynski M, Wawrzczak-Bargiela A, Przewlocki R, Przewlocka B
DOI: 10.1016/j.ejphar.2009.09.030