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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training.
Zoladz JA, Majerczak J, Grassi B, Szkutnik Z, Korostyński M, Gołda S, Grandys M, Jarmuszkiewicz W, Kilarski W, Karasinski J, Korzeniewski B
DOI: 10.1371/journal.pone.0154135
Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons.
Blazejczyk M, Macias M, Korostynski M, Firkowska M, Piechota M, Skalecka A, Tempes A, Koscielny A, Urbanska M, Przewlocki R, Jaworski J
DOI: 10.1007/s12035-016-9821-6
Seqinspector: position-based navigation through the ChIP-seq data landscape to identify gene expression regulators.
Piechota M, Korostynski M, Ficek J, Tomski A, Przewlocki R
DOI: 10.1186/s12859-016-0938-4
Transcriptional Effects of Heroin and Methamphetamine in the Striatum
Przewlocki, R., Korostynski, M., Piechota, M.
DOI: 10.1016/B978-0-12-800213-1.00087-0
Transcriptional Effects of Heroin and Methamphetamine in the Striatum
Przewlocki, R., Korostynski, M., Piechota, M.
DOI: 10.1016/B978-0-12-800213-1.00087-0
Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action
Ficek, J., Zygmunt, M., Piechota, M., Hoinkis, D., Rodriguez Parkitna, J., Przewlocki, R., Korostynski, M.
DOI: 10.1186/s12864-016-2713-3
Seqinspector: Position-based navigation through the ChIP-seq data landscape to identify gene expression regulators
Piechota, M., Korostynski, M., Ficek, J., Tomski, A., Przewlocki, R.
DOI: 10.1186/s12859-016-0938-4
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.
Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, International Stroke Genetics Consortium
DOI: 10.1212/WNL.0000000000002263
Regulation of alternative gene transcription in the striatum in response to antidepressant drugs.
Piechota M, Golda S, Ficek J, Jantas D, Przewlocki R, Korostynski M
DOI: 10.1016/j.neuropharm.2015.08.006
Opioid-dependent regulation of high and low fear responses in two inbred mouse strains.
Szklarczyk K, Korostynski M, Cieslak PE, Wawrzczak-Bargiela A, Przewlocki R
DOI: 10.1016/j.bbr.2015.06.001