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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
MicroRNA Let-7e in the Mouse Prefrontal Cortex Differentiates Restraint-Stress-Resilient Genotypes from Susceptible Genotype
Joanna Solich, Magdalena Kolasa, Agata Faron-Górecka, Jacek Hajto, Marcin Piechota, Marta Dziedzicka-Wasylewska
DOI: 10.3390/ijms22179439
Role of Non-Coding Regulatory Elements in the Control of GR-Dependent Gene Expression
Malgorzata Borczyk, Mateusz Zieba, Michał Korostyński, Marcin Piechota
DOI: 10.3390/ijms22084258
Cocaine abstinence modulates NMDA receptor subunit expression: An analysis of the GluN2B subunit in cocaine-seeking behavior
Smaga, I., Wydra, K., Piechota, M., Caffino, L., Fumagalli, F., Sanak, M., Filip, M.
DOI: 10.1016/j.pnpbp.2021.110248
Cocaine attenuates acid sphingomyelinase activity during establishment of addiction-related behavior—A translational study in rats and monkeys
Frankowska, M., Jesus, F.M., Mühle, C., Pacheco, J.V.N., Maior, R.S., Sadakierska-Chudy, A., Smaga, I., Piechota, M., Kalinichenko, L.S., Gulbins, E., Kornhuber, J., Filip, M., Müller, C.P., Barros, M.
DOI: 10.1111/adb.12955
Maternal dietary patterns are associated with susceptibility to a depressive-like phenotype in rat offspring
Gawlińska, K., Gawliński, D., Korostyński, M., Borczyk, M., Frankowska, M., Piechota, M., Filip, M., Przegaliński, E.
DOI: 10.1016/j.dcn.2020.100879
Effects of l-dopa on gene expression in the frontal cortex of rats with unilateral lesions of midbrain dopaminergic neurons
Radlicka, A., Kamińska, K., Borczyk, M., Piechota, M., Korostyński, M., Pera, J., Lorenc-Koci, E., Parkitna, J.R.
DOI: 10.1523/ENEURO.0234-20.2020
Comparison of blood pressure values and expression of genes associated with hypertension in children before and after hematopoietic cell transplantation
Strojny, W., Kwiecińska, K., Fijorek, K., Korostyński, M., Piechota, M., Balwierz, W., Skoczeń, S.
DOI: 10.1038/s41598-021-88848-7
Toll-like receptor 4-mediated cytokine synthesis and post-stroke depressive symptoms
Korostynski, M., Hoinkis, D., Piechota, M., Golda, S., Pera, J., Slowik, A., Dziedzic, T.
DOI: 10.1038/s41398-021-01359-x
Genetic Profiling in Children With Acute Lymphoblastic Leukemia Referred for Allogeneic Hematopoietic Stem Cell Transplantation
Kwiecinska, K., Strojny, W., Bik-Multanowski, M., Michal Korostynski, Piechota, M., Balwierz, W., Szymon Skoczen
DOI: 10.1177/10732748211064776
Prospects for personalization of depression treatment with genome sequencing
Borczyk, M., Piechota, M., Rodriguez Parkitna, J., Korostynski, M.
DOI: 10.1111/bph.15470