Log in
Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia
Kinga Gawlińska, Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Filip
DOI: 10.3390/ijms21217970
Gastrointestinal peptides in children before and after hematopoietic stem cell transplantation
Skoczeń, S., Rej, M., Kwiecińska, K., Pietrys, D., Tomasik, P.J., Wójcik, M., Strojny, W., Dłużniewska, A., Klimasz, K., Fijorek, K., Korostyński, M., Piechota, M., Balwierz, W.
DOI: 10.1186/s12885-020-06790-9
Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesion of midbrain dopaminergic neurons
Radlicka, A., Kamińska, K., Borczyk, M., Piechota, M., Korostyński, M., Pera, J., Lorenc-Koci, E., Parkitna, J.R.
DOI: 10.1101/2020.04.28.063347
The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction
Klimiec-Moskal, E., Piechota, M., Pera, J., Weglarczyk, K., Slowik, A., Siedlar, M., Dziedzic, T.
DOI: 10.1186/s12974-019-1691-1
Opposite regulation of piRNAs, rRNAs and miRNAs in the blood after subarachnoid hemorrhage
Morga, R., Borczyk, M., Korostynski, M., Piechota, M., Hoinkis, D., Golda, S., Dziedzic, T., Slowik, A., Moskala, M., Pera, J.
DOI: 10.1007/s00109-020-01922-x
Extinction Training after Cocaine Self-Administration Influences the Epigenetic and Genetic Machinery Responsible for Glutamatergic Transporter Gene Expression in Male Rat Brain
Smaga, I., Gawlińska, K., Frankowska, M., Wydra, K., Sadakierska-Chudy, A., Suder, A., Piechota, M., Filip, M.
DOI: 10.1016/j.neuroscience.2020.10.001
Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs
Korostynski, M., Morga, R., Piechota, M., Hoinkis, D., Golda, S., Dziedzic, T., Slowik, A., Moskala, M., Pera, J.
DOI: 10.1007/s12035-019-01789-1
Genetic Signature of Acute Lymphoblastic Leukemia and Netherton Syndrome Co-incidence—First Report in the Literature
Skoczen, S., Stepien, K., Mlynarski, W., Centkowski, P., Kwiecinska, K., Korostynski, M., Piechota, M., Wyrobek, E., Moryl-Bujakowska, A., Strojny, W., Rej, M., Kowalczyk, J., Balwierz, W.
DOI: 10.3389/fonc.2019.01477
Decoding the transcriptional programs activated by psychotropic drugs in the brain
Zygmunt, M., Piechota, M., Rodriguez Parkitna, J., Korostyński, M.
DOI: 10.1111/gbb.12511
Genetic profile and clinical implications of hepatoblastoma and neuroblastoma coexistence in a child
Skoczen, S., Stepien, K., Krzysztofik, M., Luszawska, T., Hnatko-Kolacz, M., Korostynski, M., Piechota, M., Kolanek, K., Wyrobek, L., Wysocka, K., Gorecki, W., Balwierz, W.
DOI: 10.3389/fonc.2019.00230