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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
A model of alcohol drinking under an intermittent access schedule using group-housed mice
Smutek, M., Turbasa, M., Sikora, M., Piechota, M., Zajdel, J., Przewlocki, R., Parkitna, J.R.
DOI: 10.1371/journal.pone.0096787
CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects
Bilbao, A., Rieker, C., Cannella, N., Parlato, R., Golda, S., Piechota, M., Korostynski, M., Engblom, D., Przewlocki, R., Schütz, G., Spanagel, R., Parkitna, J.R.
DOI: 10.3389/fnbeh.2014.00212
Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs.
Korostynski M, Piechota M, Dzbek J, Mlynarski W, Szklarczyk K, Ziolkowska B, Przewlocki R
DOI: 10.1186/1471-2164-14-606
Controlling complexity: the clinical relevance of mouse complex genetics.
Schughart K, Libert C, SYSGENET consortium, Kas MJ
DOI: 10.1038/ejhg.2013.79
Gene expression profiling of blood in ruptured intracranial aneurysms: in search of biomarkers.
Pera J, Korostynski M, Golda S, Piechota M, Dzbek J, Krzyszkowski T, Dziedzic T, Moskala M, Przewlocki R, Szczudlik A, Slowik A
DOI: 10.1038/jcbfm.2013.37
Gene expression profiling of blood in ruptured intracranial aneurysms: In search of biomarkers
Pera, J., Korostynski, M., Golda, S., Piechota, M., Dzbek, J., Krzyszkowski, T., Dziedzic, T., Moskala, M., Przewlocki, R., Szczudlik, A., Slowik, A.
DOI: 10.1038/jcbfm.2013.37
Astrocytes are a neural target of morphine action via glucocorticoid receptor-dependent signaling
Slezak, M., Korostynski, M., Gieryk, A., Golda, S., Dzbek, J., Piechota, M., Wlazlo, E., Bilecki, W., Przewlocki, R.
DOI: 10.1002/glia.22460
Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs
Korostynski, M., Piechota, M., Dzbek, J., Mlynarski, W., Szklarczyk, K., Ziolkowska, B., Przewlocki, R.
DOI: 10.1186/1471-2164-14-606
Astrocytes are a neural target of morphine action via glucocorticoid receptor-dependent signaling.
Slezak M, Korostynski M, Gieryk A, Golda S, Dzbek J, Piechota M, Wlazlo E, Bilecki W, Przewlocki R
DOI: 10.1002/glia.22460
Association between the A107V substitution in the δ-opioid receptors and ethanol drinking in mice selected for high and low analgesia.
Sacharczuk M, Lesniak A, Lipkowski AW, Korostynski M, Przewlocki R, Sadowski B
DOI: 10.1111/adb.12030