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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms
Korostynski, M., Piechota, M., Morga, R., Hoinkis, D., Golda, S., Zygmunt, M., Dziedzic, T., Moskala, M., Slowik, A., Pera, J.
DOI: 10.1186/s12967-019-1891-6
Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model
Korostynski, M., Malek, N., Piechota, M., Starowicz, K.
DOI: 10.1007/s10142-017-0576-6
Whole-exome sequencing identifies novel pathogenic mutations and putative phenotype-influencing variants in Polish limb-girdle muscular dystrophy patients
Fichna, J.P., MacIas, A., Piechota, M., Korostynski, M., Potulska-Chromik, A., Redowicz, M.J., Zekanowski, C.
DOI: 10.1186/s40246-018-0167-1
Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs
Zygmunt, M., Hoinkis, D., Hajto, J., Piechota, M., Skupień-Rabian, B., Jankowska, U., Kȩdracka-Krok, S., Rodriguez Parkitna, J., Korostyński, M.
DOI: 10.1186/s12868-018-0458-4
Transcriptional signatures of steroid hormones in the striatal neurons and astrocytes
Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara, Ryszard Przewlocki
DOI: 10.1186/s12868-017-0352-5
Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis
Korostyński, M., Małek, N., Piechota, M., Starowicz, K.
DOI: 10.1155/2017/1746426
Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons
Blazejczyk, M., Macias, M., Korostynski, M., Firkowska, M., Piechota, M., Skalecka, A., Tempes, A., Koscielny, A., Urbanska, M., Przewlocki, R., Jaworski, J.
DOI: 10.1007/s12035-016-9821-6
Looking for new diagnostic tools and biomarkers of hypertension in obese pediatric patients
Strojny, W., Drozdz, D., Fijorek, K., Korostynski, M., Piechota, M., Balwierz, W., Pietrzyk, J.A., Kwinta, P., Siedlar, M., Skoczen, S.
DOI: 10.1097/MBP.0000000000000242
Behavioral and transcriptional patterns of protracted opioid self-administration in mice
Skupio, U., Sikora, M., Korostynski, M., Wawrzczak-Bargiela, A., Piechota, M., Ficek, J., Przewlocki, R.
DOI: 10.1111/adb.12449
Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action.
Ficek J, Zygmunt M, Piechota M, Hoinkis D, Rodriguez Parkitna J, Przewlocki R, Korostynski M
DOI: 10.1186/s12864-016-2713-3