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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain.
Obara I, Parkitna JR, Korostynski M, Makuch W, Kaminska D, Przewlocka B, Przewlocki R
DOI: 10.1016/j.pain.2008.12.006
Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategy.
Ligeza A, Wawrzczak-Bargiela A, Kaminska D, Korostynski M, Przewlocki R
DOI: 10.1111/j.1742-4658.2008.06531.x
Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays.
Jura J, Wegrzyn P, Korostyński M, Guzik K, Oczko-Wojciechowska M, Jarzab M, Kowalska M, Piechota M, Przewłocki R, Koj A
DOI: 10.1016/j.bbagrm.2008.04.006
Interleukin-1 alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model.
Mika J, Korostynski M, Kaminska D, Wawrzczak-Bargiela A, Osikowicz M, Makuch W, Przewlocki R, Przewlocka B
DOI: 10.1016/j.pain.2008.02.015
Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays
Jura, J., Wegrzyn, P., Korostyński, M., Guzik, K., Oczko-Wojciechowska, M., Jarzab, M., Kowalska, M., Piechota, M., Przewłocki, R., Koj, A.
DOI: 10.1016/j.bbagrm.2008.04.006
Morphine effects on striatal transcriptome in mice
Korostynski, M., Piechota, M., Kaminska, D., Solecki, W., Przewlocki, R.
DOI: 10.1186/gb-2007-8-6-r128
Morphine effects on striatal transcriptome in mice.
Korostynski M, Piechota M, Kaminska D, Solecki W, Przewlocki R
DOI: 10.1186/gb-2007-8-6-r128
Comparison of gene expression profiles in neuropathic and inflammatory pain.
Rodriguez Parkitna J, Korostynski M, Kaminska-Chowaniec D, Obara I, Mika J, Przewlocka B, Przewlocki R
DOI:
Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes.
Korostynski M, Kaminska-Chowaniec D, Piechota M, Przewlocki R
DOI: 10.1186/1471-2164-7-146
Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes
Korostynski, M., Kaminska-Chowaniec, D., Piechota, M., Przewlocki, R.
DOI: 10.1186/1471-2164-7-146