Log in
Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post‐stroke depressive symptoms: Proof‐of‐concept study
Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic
DOI: 10.1111/jnc.15902
PharmGScore scores of compound genetic variant burden for psychiatric treatment optimization
Malgorzata Borczyk, Jacek Hajto, Marcin Piechota, Michal Korostynski
DOI: 10.1101/2023.06.27.23291888
Glucocorticoid-Regulated Kinase CAMKIγ in the Central Amygdala Controls Anxiety-like Behavior in Mice
Marcin Piechota, Urszula Skupio, Małgorzata Borczyk, Barbara Ziółkowska, Sławomir Gołda, Łukasz Szumiec, Klaudia Szklarczyk-Smolana, Wiktor Bilecki, Jan Manuel Rodriguez Parkitna, Michał Korostyński
DOI: 10.3390/ijms232012328
Transcriptional Response of Blood Mononuclear Cells from Patients with Inflammatory and Autoimmune Disorders Exposed to “Krakow Smog”
Adrianna Gałuszka-Bulaga, Jacek Hajto, Małgorzata Borczyk, Sławomir Gołda, Marcin Piechota, Michał Korostyński, Magdalena Rutkowska-Zapała, Paweł Latacz, Zofia Guła, Mariusz Korkosz, Joanna Pera, Agnieszka Słowik, Maciej Siedlar, Jarek Baran
DOI: 10.3390/cells11162586
TTN Variants Are Associated with Physical Performance and Provide Potential Markers for Sport-Related Phenotypes
Agata Leońska-Duniec, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Andrzej Brodkiewicz, Paweł Cięszczyk
DOI: 10.3390/ijerph191610173
Gene Expression Changes Induced by Exposure of RAW 264.7 Macrophages to Particulate Matter of Air Pollution: The Role of Endotoxins
Adam Roman, Michał Korostyński, Monika Jankowska-Kieltyka, Marcin Piechota, Jacek Hajto, Irena Nalepa
DOI: 10.3390/biom12081100
Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes
Magdalena Dzitkowska-Zabielska, Aleksandra Bojarczuk, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Jakub Grzegorz Adamczyk, Grzegorz Trybek, Myosotis Massidda, Paweł Cięszczyk
DOI: 10.3390/genes13050870
Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program
Katarzyna Świtała, Aleksandra Bojarczuk, Jacek Hajto, Marcin Piechota, Maciej Buryta, Agata Leońska-Duniec
DOI: 10.3390/ijerph19094942
Deletion in the Y chromosome of B10.BR-Y<sup>del</sup> mice alters transcription from MSYq genes and has moderate effect on DNA methylation
Kotarska, K., Doniec, A., Korostyński, M., Piechota, M., Gołas, A., Lisowski, P., Styrna, J.
DOI: 10.1016/j.repbio.2022.100614
Oligogenic risk model for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders
Malgorzata Borczyk, Jakub P Fichna, Marcin Piechota, Sławomir Gołda, Mateusz Zięba, Dzesika Hoinkis, Paweł Cięszczyk, Michal Korostyński, Piotr Janik, Cezary Żekanowski
DOI: 10.1101/2021.12.09.21266782