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Laboratory of Pharmacogenomics
Scientific profile
- About department
- Employees
The research conducted in the Laboratory of Pharmacogenomics is focused on the identification of biological correlates and molecular mechanisms related to pharmacotherapy. Our goal is to indicate new druggable targets, indicators of treatment safety, and gene-drug interactions of clinical relevance. The research concerns psychotropic drugs used in the treatment of depression, psychotic and anxiety disorders, and other psychoactive compounds. The studies are carried out at the level of genes, both in terms of differences in DNA sequence between humans as well as alterations in the transcript expression.
We use bioinformatics tools for the analysis and interpretation of large genomic data sets. The results are obtained using next-generation sequencing technology (NGS), which enables the scale measurements of the full sequence of genomes and transcriptomes. High-throughput sequencing allows for both associative genetic studies as well as the measurement of changes in the expression level of different classes of RNA and genes isoforms.
+48 12 6623259
michkor@if-pan.krakow.pl
room 134 Pracownicy zakładu
Achievements
- Publications
Genotype-dependent consequences of traumatic stress in four inbred mouse strains.
Szklarczyk K, Korostynski M, Golda S, Solecki W, Przewlocki R
DOI: 10.1111/j.1601-183x.2012.00850.x
GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects.
Grzywacz A, Małecka I, Korostyński M, Przewłocki R, Bieńkowski P, Samochowiec J
DOI: 10.5114/aoms.2012.28565
Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine.
Piechota M, Korostynski M, Sikora M, Golda S, Dzbek J, Przewlocki R
DOI: 10.1111/j.1601-183x.2012.00777.x
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice
Ziółkowska, B., Korostyński, M., Piechota, M., Kubik, J., Przewołcki, R.
DOI: 10.1016/S1734-1140(12)70906-4
Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine
Piechota, M., Korostynski, M., Sikora, M., Golda, S., Dzbek, J., Przewlocki, R.
DOI: 10.1111/j.1601-183X.2012.00777.x
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice.
Ziółkowska B, Korostyński M, Piechota M, Kubik J, Przewłocki R
DOI: 10.1016/s1734-1140(12)70906-4
Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans.
Majerczak J, Korostynski M, Nieckarz Z, Szkutnik Z, Duda K, Zoladz JA
DOI: 10.1113/expphysiol.2011.062992
Neuropsin cleaves EphB2 in the amygdala to control anxiety.
Attwood BK, Bourgognon JM, Patel S, Mucha M, Schiavon E, Skrzypiec AE, Young KW, Shiosaka S, Korostynski M, Piechota M, Przewlocki R, Pawlak R
DOI: 10.1038/nature09938
Neuropsin cleaves EphB2 in the amygdala to control anxiety
Attwood, B.K., Bourgognon, J.-M., Patel, S., Mucha, M., Schiavon, E., Skrzypiec, A.E., Young, K.W., Shiosaka, S., Korostynski, M., Piechota, M., Przewlocki, R., Pawlak, R.
DOI: 10.1038/nature09938
New operant model of reinstatement of food-seeking behavior in mice.
Martín-García E, Burokas A, Kostrzewa E, Gieryk A, Korostynski M, Ziolkowska B, Przewlocka B, Przewlocki R, Maldonado R
DOI: 10.1007/s00213-010-2110-6