Department of Molecular Neuropharmacology

Scientific profile

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Our research focuses on three areas: the reward system of the brain, the molecular mechanisms of drug action, and neuro-pharmacogenomics.

The reward system of the brain encompasses all brain areas involved in reward-driven behaviors, with the mesolimbic dopamine system at the core. We have been studying the mechanisms involved in the plasticity of dopaminergic and dopaminoceptive neurons, and also the role of endogenous opioids in signaling rewards.

As the name of the Department implies a large part of our research focuses on the cellular and the molecular mechanisms of actions of psychotropic drugs, also with an emphasis on opioids. We hope that elucidating molecular signatures of drug action will lead to the identification of mechanisms essential for their therapeutic effects.

In recent years we have also been involved in neuro-pharmacogenomics, searching for associations between genetic background, neuropsychiatric disorders, and the effectiveness of pharmacotherapy. We use next-generation sequencing to discover novel common as well as rare genetic variants associated with drug effectiveness and safety. This is of particular interest in psychiatry due to large interindividual differences in therapy responses.

Jan Manuel Rodriguez Parkitna

Professor Jan Manuel Rodriguez Parkitna, dr hab.

Head

+48 12 6623316
room 210

Pracownicy zakładu

Professor Ryszard Przewłocki, dr hab.

+48 12 6623218
room 140

Michał Korostyński, dr hab.

+48 12 6623259
room 134

Marcin Piechota, dr

+48 12 6623259
room 134

Ganna Shayakhmetova, dr

Małgorzata Borczyk, dr

Sławomir Gołda, dr

+48 12 6623259
room 134

Zofia Harda, dr

+48 12 6623328
room 127

Alla Voronina, dr

Barbara Ziółkowska, dr hab.

+48 12 6623238
room 131

Łukasz Szumiec, mgr

+48 12 6623328
room 127

Lidia Radwan, mgr

+48 12 6623238
room 140

Jacek Hajto, mgr

+48 12 6623259
room 131

Klaudia Misiołek, mgr

+48 12 6623328
room 127

Magdalena Ziemiańska, mgr

+48 12 6623328
room 127

Mateusz Zięba, mgr

+48 12 6623259
room 131

Pracownicy pracowni

Michał Korostyński, dr hab.

+48 12 6623259
room 134

Marcin Piechota, dr

+48 12 6623259
room 134

Małgorzata Borczyk, dr

Jacek Hajto, mgr

+48 12 6623259
room 131

Mateusz Zięba, mgr

+48 12 6623259
room 131

Laboratory of Pharmacogenomics

Headdr hab. Michał Korostyński

Achievements

  • Publications
  • Grants
  • Awards

Grant

The developmental changes in the endogenous opioid system associated with altered sensitivity to reward during adolescence

Klaudia Misiołek, MSc

Grant

Kappa opioid receptors integrate neuronal signaling involved in social behavior

Professor Jan Manuel Rodriguez Parkitna, PhD

Award

The Jerzy Konorski Team Award for the best study in neurobiology conducted in Poland awarded every year by the Polish Neuroscience Society and Committee of Neurobiology of the Polish Academy of Sciences

Professor Jan Manuel Rodriguez Parkitna, PhD

Inflammation-Driven Secretion Potential Is Upregulated in Osteoarthritic Fibroblast-Like Synoviocytes

Jakub Chwastek, Marta Kędziora, Małgorzata Borczyk, Michał Korostyński, Katarzyna Starowicz

DOI: 10.3390/ijms231911817

Prospects for personalization of depression treatment with genome sequencing

Malgorzata Borczyk, Marcin Piechota, Jan Rodriguez Parkitna, Michal Korostynski

DOI: 10.1111/bph.15470

Transcriptional Response of Blood Mononuclear Cells from Patients with Inflammatory and Autoimmune Disorders Exposed to “Krakow Smog”

Adrianna Gałuszka-Bulaga, Jacek Hajto, Małgorzata Borczyk, Sławomir Gołda, Marcin Piechota, Michał Korostyński, Magdalena Rutkowska-Zapała, Paweł Latacz, Zofia Guła, Mariusz Korkosz, Joanna Pera, Agnieszka Słowik, Maciej Siedlar, Jarek Baran

DOI: 10.3390/cells11162586

TTN Variants Are Associated with Physical Performance and Provide Potential Markers for Sport-Related Phenotypes

Agata Leońska-Duniec, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Andrzej Brodkiewicz, Paweł Cięszczyk

DOI: 10.3390/ijerph191610173

Gene Expression Changes Induced by Exposure of RAW 264.7 Macrophages to Particulate Matter of Air Pollution: The Role of Endotoxins

Adam Roman, Michał Korostyński, Monika Jankowska-Kieltyka, Marcin Piechota, Jacek Hajto, Irena Nalepa

DOI: 10.3390/biom12081100

Deletion in the Y chromosome of B10.BR-Ydel mice alters transcription from MSYq genes and has moderate effect on DNA methylation

Katarzyna Kotarska, Andrzej Doniec, Michał Korostyński, Marcin Piechota, Aniela Gołas, Paweł Lisowski, Józefa Styrna

DOI: 10.1016/j.repbio.2022.100614

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Magdalena Dzitkowska-Zabielska, Aleksandra Bojarczuk, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Jakub Grzegorz Adamczyk, Grzegorz Trybek, Myosotis Massidda, Paweł Cięszczyk

DOI: 10.3390/genes13050870

Downregulation of dystrophin expression occurs across diverse tumors, correlates with the age of onset, staging and reduced survival of patients

Alnassar, N., Borczyk, M., Tsagkogeorga, G., Korostynski, M., Han, N., Górecki, D.C.

DOI: 10.1101/2022.04.04.486990

Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

Gosselin, M.R.F., Mournetas, V., Borczyk, M., Verma, S., Occhipinti, A., Róg, J., Bozycki, L., Korostynski, M., Robson, S.C., Angione, C., Pinset, C., Gorecki, D.C.

DOI: 10.7554/eLife.75521

Oligogenic risk model for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders

Malgorzata Borczyk, Jakub P Fichna, Marcin Piechota, Sławomir Gołda, Mateusz Zięba, Dzesika Hoinkis, Paweł Cięszczyk, Michal Korostyński, Piotr Janik, Cezary Żekanowski

DOI: 10.1101/2021.12.09.21266782

Head

Professor Jan Manuel Rodriguez Parkitna, dr hab.

+48 12 6623316
room 210

See also