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Department of Molecular Neuropharmacology
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Our research focuses on three areas: the reward system of the brain, the molecular mechanisms of drug action, and neuro-pharmacogenomics.
The reward system of the brain encompasses all brain areas involved in reward-driven behaviors, with the mesolimbic dopamine system at the core. We have been studying the mechanisms involved in the plasticity of dopaminergic and dopaminoceptive neurons, and also the role of endogenous opioids in signaling rewards.
As the name of the Department implies a large part of our research focuses on the cellular and the molecular mechanisms of actions of psychotropic drugs, also with an emphasis on opioids. We hope that elucidating molecular signatures of drug action will lead to the identification of mechanisms essential for their therapeutic effects.
In recent years we have also been involved in neuro-pharmacogenomics, searching for associations between genetic background, neuropsychiatric disorders, and the effectiveness of pharmacotherapy. We use next-generation sequencing to discover novel common as well as rare genetic variants associated with drug effectiveness and safety. This is of particular interest in psychiatry due to large interindividual differences in therapy responses.
Professor Jan Manuel Rodriguez Parkitna, dr hab.
Head
+48 12 6623316
janrod@if-pan.krakow.pl
room 210 Pracownicy zakładu
Professor Ryszard Przewłocki, dr hab.
+48 12 6623218nfprzewl@cyf-kr.edu.plroom 140Michał Korostyński, dr hab.
+48 12 6623259michkor@if-pan.krakow.plroom 134Marcin Piechota, dr
+48 12 6623259marpiech@if-pan.krakow.plroom 134Ganna Shayakhmetova, dr
shayakh@if-pan.krakow.plMałgorzata Borczyk, dr
gosborcz@if-pan.krakow.plSławomir Gołda, dr
+48 12 6623259slawgo@if-pan.krakow.plroom 134Zofia Harda, dr
+48 12 6623328harda@if-pan.krakow.plroom 127Alla Voronina, dr
voronina@if-pan.krakow.plBarbara Ziółkowska, dr hab.
+48 12 6623238nfziolko@cyf-kr.edu.plroom 131Łukasz Szumiec, mgr
+48 12 6623328szumiec@if-pan.krakow.plroom 127Lidia Radwan, mgr
+48 12 6623238radwan@if-pan.krakow.plroom 140Jacek Hajto, mgr
+48 12 6623259hajto@if-pan.krakow.plroom 131Klaudia Misiołek, mgr
+48 12 6623328misiolek@if-pan.krakow.plroom 127Magdalena Ziemiańska, mgr
+48 12 6623328mziemian@if-pan.krakow.plroom 127Mateusz Zięba, mgr
+48 12 6623259m.zieba@if-pan.krakow.plroom 131Pracownicy pracowni
Michał Korostyński, dr hab.
+48 12 6623259michkor@if-pan.krakow.plroom 134Marcin Piechota, dr
+48 12 6623259marpiech@if-pan.krakow.plroom 134Małgorzata Borczyk, dr
gosborcz@if-pan.krakow.plJacek Hajto, mgr
+48 12 6623259hajto@if-pan.krakow.plroom 131Mateusz Zięba, mgr
+48 12 6623259m.zieba@if-pan.krakow.plroom 131Achievements
- Publications
- Grants
- Awards
Grant
The developmental changes in the endogenous opioid system associated with altered sensitivity to reward during adolescence
Klaudia Misiołek, MSc
Grant
Kappa opioid receptors integrate neuronal signaling involved in social behavior
Professor Jan Manuel Rodriguez Parkitna, PhD
Award
The Jerzy Konorski Team Award for the best study in neurobiology conducted in Poland awarded every year by the Polish Neuroscience Society and Committee of Neurobiology of the Polish Academy of Sciences
Professor Jan Manuel Rodriguez Parkitna, PhD
Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes.
Korostynski M, Kaminska-Chowaniec D, Piechota M, Przewlocki R
DOI: 10.1186/1471-2164-7-146
Comparison of gene expression profiles in neuropathic and inflammatory pain
Parkitna, J.R., Korostynski, M., Kaminska-Chowaniec, D., Obara, I., Mika, J., Przewlocka, B., Przewlocki, R.
DOI: