dr hab. Sabina Podlewska

dr hab. Sabina Podlewska

+48 12 6623301
pokój 326
Zakład Chemii Leków

Dokonania naukowe

  • Publikacje

Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain

Autorzy: Katarzyna Szczepańska, Tadeusz Karcz, Maria Dichiara, Szczepan Mogilski, Justyna Kalinowska-Tłuścik, Bogusław Pilarski, Arkadiusz Leniak, Wojciech Pietruś, Sabina Podlewska, Katarzyna Popiołek-Barczyk, Laura J. Humphrys, M. Carmen Ruiz-Cantero, David Reiner-Link, Luisa Leitzbach, Dorota Łażewska, Steffen Pockes, Michał Górka, Adam Zmysłowski, Thierry Calmels, Enrique J. Cobos, Agostino Marrazzo, Holger Stark, Andrzej J. Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz

DOI: 10.1021/acs.jmedchem.3c00430
Date: 2023-07-27

Generative Models Should at Least Be Able to Design Molecules That Dock Well: A New Benchmark

Autorzy: Tobiasz Ciepliński, Tomasz Danel, Sabina Podlewska, Stanisław Jastrzȩbski

DOI: 10.1021/acs.jcim.2c01355
Date: 2023-06-12

Multitargeting the Action of 5-HT6 Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer’s Disease: Can It Work from a Molecular Point of View?

Autorzy: Kinga Czarnota-Łydka, Katarzyna Kucwaj-Brysz, Patryk Pyka, Wawrzyniec Haberek, Sabina Podlewska, Jadwiga Handzlik

DOI: 10.3390/ijms23158768
Date: 2022-08-07

In Vitro and In Silico Analysis of the Residence Time of Serotonin 5-HT7 Receptor Ligands with Arylpiperazine Structure: A Structure–Kinetics Relationship Study

Autorzy: Eduardo Penna, Mauro Niso, Sabina Podlewska, Floriana Volpicelli, Marianna Crispino, Carla Perrone-Capano, Andrzej J. Bojarski, Enza Lacivita, Marcello Leopoldo

DOI: 10.1021/acschemneuro.1c00710
Date: 2022-02-16

Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

Autorzy: Katarzyna Szczepańska, Sabina Podlewska, Maria Dichiara, Davide Gentile, Vincenzo Patamia, Niklas Rosier, Denise Mönnich, Ma Carmen Ruiz Cantero, Tadeusz Karcz, Dorota Łażewska, Agata Siwek, Steffen Pockes, Enrique J. Cobos, Agostino Marrazzo, Holger Stark, Antonio Rescifina, Andrzej J. Bojarski, Emanuele Amata, Katarzyna Kieć-Kononowicz

DOI: 10.1021/acschemneuro.1c00435
Date: 2022-01-05

Comparison of an Addictive Potential of μ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies

Autorzy: Lucja Kudla, Ryszard Bugno, Sabina Podlewska, Lukasz Szumiec, Lucja Wiktorowska, Andrzej J. Bojarski, Ryszard Przewlocki

DOI: 10.3390/pharmaceutics14010055
Date: 2021-12-27

How can SHAP values help to shape metabolic stability of chemical compounds?

Autorzy: Agnieszka Wojtuch, Rafał Jankowski, Sabina Podlewska

DOI: 10.1186/s13321-021-00542-y
Date: 2021-12-01

The Structural Determinants for α1-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

Autorzy: Katarzyna Kucwaj-Brysz, Anna Dela, Sabina Podlewska, Marek Bednarski, Agata Siwek, Grzegorz Satała, Kinga Czarnota, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz

DOI: 10.3390/molecules26227025
Date: 2021-11-20

Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections

Autorzy: Iwona E. Głowacka, Magdalena Grabkowska-Drużyc, Graciela Andrei, Dominique Schols, Robert Snoeck, Karolina Witek, Sabina Podlewska, Jadwiga Handzlik, Dorota G. Piotrowska

DOI: 10.3390/ijms22158032
Date: 2021-07-27

Optimization of Metabolic Stability of Ligands of Serotonin Receptor 5-HT7 Using SHAP Values

Autorzy: Agnieszka Wojtuch, Rafał Jankowski, Sabina Podlewska

DOI: 10.3390/ECB2021-10258
Date: 2021-05-31

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