Department of Molecular Neuropharmacology

Scientific profile

  • About department
  • Employees
  • Laboratories

Our research focuses on three areas: the reward system of the brain, the molecular mechanisms of drug action, and neuro-pharmacogenomics.

The reward system of the brain encompasses all brain areas involved in reward-driven behaviors, with the mesolimbic dopamine system at the core. We have been studying the mechanisms involved in the plasticity of dopaminergic and dopaminoceptive neurons, and also the role of endogenous opioids in signaling rewards.

As the name of the Department implies a large part of our research focuses on the cellular and the molecular mechanisms of actions of psychotropic drugs, also with an emphasis on opioids. We hope that elucidating molecular signatures of drug action will lead to the identification of mechanisms essential for their therapeutic effects.

In recent years we have also been involved in neuro-pharmacogenomics, searching for associations between genetic background, neuropsychiatric disorders, and the effectiveness of pharmacotherapy. We use next-generation sequencing to discover novel common as well as rare genetic variants associated with drug effectiveness and safety. This is of particular interest in psychiatry due to large interindividual differences in therapy responses.

Jan Manuel Rodriguez Parkitna

Professor Jan Manuel Rodriguez Parkitna, dr hab.

Head

+48 12 6623316
room 210

Pracownicy zakładu

Professor Ryszard Przewłocki, dr hab.

+48 12 6623218
room 140

Michał Korostyński, dr hab.

+48 12 6623259
room 134

Marcin Piechota, dr

+48 12 6623259
room 134

Ganna Shayakhmetova, dr

Małgorzata Borczyk, dr

Sławomir Gołda, dr

+48 12 6623259
room 134

Zofia Harda, dr

+48 12 6623328
room 127

Alla Voronina, dr

Barbara Ziółkowska, dr hab.

+48 12 6623238
room 131

Łukasz Szumiec, mgr

+48 12 6623328
room 127

Lidia Radwan, mgr

+48 12 6623238
room 140

Jacek Hajto, mgr

+48 12 6623259
room 131

Klaudia Misiołek, mgr

+48 12 6623328
room 127

Magdalena Ziemiańska, mgr

+48 12 6623328
room 127

Mateusz Zięba, mgr

+48 12 6623259
room 131

Pracownicy pracowni

Michał Korostyński, dr hab.

+48 12 6623259
room 134

Marcin Piechota, dr

+48 12 6623259
room 134

Małgorzata Borczyk, dr

Jacek Hajto, mgr

+48 12 6623259
room 131

Mateusz Zięba, mgr

+48 12 6623259
room 131

Laboratory of Pharmacogenomics

Headdr hab. Michał Korostyński

Achievements

  • Publications
  • Grants
  • Awards

Grant

The developmental changes in the endogenous opioid system associated with altered sensitivity to reward during adolescence

Klaudia Misiołek, MSc

Grant

Kappa opioid receptors integrate neuronal signaling involved in social behavior

Professor Jan Manuel Rodriguez Parkitna, PhD

Award

The Jerzy Konorski Team Award for the best study in neurobiology conducted in Poland awarded every year by the Polish Neuroscience Society and Committee of Neurobiology of the Polish Academy of Sciences

Professor Jan Manuel Rodriguez Parkitna, PhD

NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency

Jaroslaw Cendrowski, Marta Wrobel, Michal Mazur, Bartosz Jary, Surui Wang, Michal Korostynski, Anna Dziewulska, Maria Rohm, Agnieszka Dobrzyn, Anja Zeigerer, Marta Miaczynska

DOI: 10.1101/2024.06.12.598606

Mimicking the Human Articular Joint with In Vitro Model of Neurons-Synoviocytes Co-Culture

Jakub Chwastek, Marta Kędziora, Małgorzata Borczyk, Michał Korostyński, Katarzyna Starowicz

DOI: 10.15283/ijsc23043

Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post‐stroke depressive symptoms: Proof‐of‐concept study

Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic

DOI: 10.1111/jnc.15902

The First Potentially Causal Genetic Variant Documented in a Polish Woman with Multiple Cavernous Malformations of the Brain

Elżbieta Szczygieł-Pilut, Daniel Pilut, Michal Korostynski, Piotr Kopiński, Daniel P. Potaczek, Ewa Wypasek

DOI: 10.3390/genes14081535

PharmGScore scores of compound genetic variant burden for psychiatric treatment optimization

Malgorzata Borczyk, Jacek Hajto, Marcin Piechota, Michal Korostynski

DOI: 10.1101/2023.06.27.23291888

Genomic variants and inferred biological processes in multiplex families with Tourette syndrome

Fichna, J.P., Borczyk, M., Piechota, M., Korostynski, M., Zekanowski, C., Janik, P.

DOI: 10.1503/jpn.220206

Downregulation of Dystrophin Expression Occurs across Diverse Tumors, Correlates with the Age of Onset, Staging and Reduced Survival of Patients

Alnassar, N., Borczyk, M., Tsagkogeorga, G., Korostynski, M., Han, N., Górecki, D.C.

DOI: 10.3390/cancers15051378

Astrocytic Foxo1 regulates hippocampal spinogenesis and synaptic plasticity to enhance fear memory

Viana, J.F., Guerra-Gomes, S., Abreu, D.S., Machado, J.L., Barsanti, S., Gonçalves, M., Martín-Monteagudo, C., Sardinha, V.M., Nascimento, D.S.M., Tavares, G., Irmler, M., Beckers, J., Korostynski, M., Sousa, N., Navarrete, M., Teixeira-Castro, A., Pinto, L., Oliveira, J.F.

DOI: 10.1101/2023.05.01.538923

A Patient with Corticobasal Syndrome and Progressive Non-Fluent Aphasia (CBS-PNFA), with Variants in ATP7B, SETX, SORL1, and FOXP1 Genes

Katarzyna Gaweda-Walerych, Emilia J. Sitek, Małgorzata Borczyk, Ewa Narożańska, Bogna Brockhuis, Michał Korostyński, Michał Schinwelski, Mariusz Siemiński, Jarosław Sławek, Cezary Zekanowski

DOI: 10.3390/genes13122361

Glucocorticoid-Regulated Kinase CAMKIγ in the Central Amygdala Controls Anxiety-like Behavior in Mice

Marcin Piechota, Urszula Skupio, Małgorzata Borczyk, Barbara Ziółkowska, Sławomir Gołda, Łukasz Szumiec, Klaudia Szklarczyk-Smolana, Wiktor Bilecki, Jan Manuel Rodriguez Parkitna, Michał Korostyński

DOI: 10.3390/ijms232012328

Head

Professor Jan Manuel Rodriguez Parkitna, dr hab.

+48 12 6623316
room 210

See also